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The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds

There are no head-to-head clinical trials proving one is superior to the other

Calorie reduction and dietary changes can sometimes contribute to lower nutrient intake, which may leave people feeling fatigued or run down